
Design
The ORCA-3 trial mirrors the Phase 3 ORCA-2 trial and is designed to obtain additional safety and efficacy data.
- Placebo-controlled & double-blind
- 3 treatment arms: Placebo vs 6 or 12 weeks cytisinicline
Cytisinicline treatment for 6 or 12 weeks
- Does longer treatment lead to better efficacy?
- Does continued treatment prevent early relapses?
- Primary Endpoint: 4-week continuous abstinence ON treatment
- Follow up to 6 months


ORCA-3 Trial Locations
ORCA-3 is being conducted at the following locations in the US.
https://velocityclinical.com/locations/velocity-clinical-research-cleveland
216-682-0320
Aventiv Research, Inc.
https://www.aventivresearch.com/clinical_study/smoking-cessation/
614-501-6164 Ext. 2023
Accel Clinical Research
https://accelresearchsites.com/find-a-trial/all-conditions/smoking-cessation-nicotine-addiction/
386-785-2400 Ext. 399
Altoona Center for Clinical Research
https://www.altoonaarthritis.com/
800-924-7790 ext. 188
MediSphere Medical Research Center, LLC
https://www.medisphereresearch.com/
812-471-4110
Insight Research Institute
https://insightresearchinstitute.com/
810-213-8088
Alliance For Multispecialty Research
(AMR Fort Myers)
https://clinicalstudycenter.com/smoking-cessation-clinical-research-study/
239-908-0495
Jacksonville Center for Clinical Research
https://encoredocs.com/portfolio/smoking-cessation/
904-730-0101
Little Rock Allergy & Asthma Clinic
https://www.littlerockallergy.com/
1-800-514-4343
ActivMed Practices and Research
https://activmedresearch.com/join-a-trial/methuen-ma/#!/study/614
978-655-1755
Clinical Research Associates, Inc.
https://clinicalresearchassociates.com/stop-smoking/
615-329-0197 Ext. 231
Health Research of Hampton Roads, Inc.
https://hrhr-inc.com/smoking-cessation/
757-591-8100
Intend Research
http://intendresearch.com/currently-enrolling-studies/
405-701-8999
Affinity Health
https://affinityhealthcorp.com/smoking-cessation-clinical-study/
630-835-0556
Alliance for Multispecialty Research
(AMR Phoenix)
https://crctrials.com/smoking-cessation/
602-759-7559
Global Medical Institutes
https://www.gminstitutes.com/clinical-trials-for-quitting-smoking/
609-921-3555 Ext. 110
Clinical Trials of Texas, LLC
https://saresearch.com/studies/#!/study/1166/
210-949-0122
Precision Clinical Research
https://pcrflorida.com/studies/smoking-cessation/
954-715-2990
Trial Management Associates, Inc.
https://www.trialmgt.com/contact-us/
910-833-1954